Mgr. David KOPEČNÝ, Ph.D.
Telephone:
585634840,585634848
Workplace:
Katedra experimentální biologie
Org. unit:
Přírodovědecká fakulta
Address:
Šlechtitelů 27 - objekt F2 (CRH)
Room number:
1.28
Profession:
odborný asistent
Activity:
crystallography, biochemistry and enzymology of plant proteins
ČLÁNEK
Nisler J., Klimeš P., Končitíková R., Kadlecová A., Voller J., Kopečný D., De Diego Sanchez N., Spíchal L.
Cytokinin oxidase/dehydrogenase inhibitors: progress towards agricultural practice.
JOURNAL OF EXPERIMENTAL BOTANY.
2024.
Ľuptáková E., Vigouroux A., Končitíková R., Kopečná M., Zalabák D., Novák O., Salcedo Sarmiento S., Ćavar Zeljković S., Kopečný D., Strnad M., Spíchal L., De Diego Sanchez N., Kopečný D.
Plant nucleoside N-ribohydrolases: riboside binding and role in nitrogen storage mobilization.
PLANT JOURNAL.
2024.
Brunoni F., Pěnčík A., Žukauskaite A., Ament A., Kopečná M., Collani S., Kopečný D., Novák O.
Amino acid conjugation of oxIAA is a secondary metabolic regulation involved in auxin homeostasis.
NEW PHYTOLOGIST.
2023.
Bělíček J., Ľuptáková E., Kopečný D., Frömmel J., Ćavar Zeljković S., Kopečný D., Tarkowski P., Nisler J., De Diego Sanchez N., Kopečná M.
Biochemical and structural basis of polyamine, lysine and ornithine acetylation catalyzed by spermine/spermidine N-acetyl transferase in moss and maize.
PLANT JOURNAL.
2023.
Opatíková M., Semchonok DA., Kopečný D., Ilík P., Pospíšil P., Ćavar Zeljković S., Tarkowski P., Kouřil R.
Cryo-EM structure of a plant photosystem II supercomplex with light-harvesting protein Lhcb8 and α-tocopherol.
Nature Plants (online).
2023.
Ondrová K., Zůvalová I., Vyhlídalová B., Krasulová K., Miková E., Vrzal R., Nádvorník P., Kopečná M., Kopečný D., Šebela M., Soural M., Dvořák Z.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Nature Communications.
2023.
Suazo KF., Bělíček J., Schey GL., Kopečný D., Distefano MD.
Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1.
RSC CHEMICAL BIOLOGY.
2023.
Nisler J., Pěkná Z., Končitíková R., Klimeš P., Kadlecová A., Plačková L., Zalabák D., Spíchal L., Strnad M., Kopečný D.
Cytokinin oxidase/dehydrogenase inhibitors: outlook for selectivity and high efficiency.
JOURNAL OF EXPERIMENTAL BOTANY.
2022.
Hernychová L., Alexandri E., Tzakos AG., Zatloukalová M., Primikyri A., Gerothanassis IP., Uhrik L., Šebela M., Kopečný D., Jedinák L., Vacek J.
Serum albumin as a primary non-covalent binding protein for nitro-oleic acid.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.
2022.
Nisler J., Kopečný D., Pěkná Z., Končitíková R., Koprna R., De Diego Sanchez N., Kopečná M., Zalabák D., Spíchal L., Strnad M.
Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture.
JOURNAL OF EXPERIMENTAL BOTANY.
2021.
Oliveira DM., Mota TR., Salatta FV., Končitíková R., Kopečný D.
Cell wall remodeling under salt stress: Insights into changes in polysaccharides, feruloylation, lignification, and phenolic metabolism in maize.
PLANT CELL AND ENVIRONMENT.
2020.
Jaworek P., Tarkowski P., Hluska T., Kouřil Š., Vrobel O., Nisler J., Kopečný D.
Characterization of five CHASE‑containing histidine kinase receptors from Populus × canadensis cv. Robusta sensing isoprenoid and aromatic cytokinins.
PLANTA.
2020.
Jacques F., Zhao Y., Kopečná M., Končitíková R., Kopečný D., Rippa S., Perrin Y.
Roles for ALDH10 enzymes in gamma-butyrobetaine synthesis, seed development, germination, and salt tolerance in Arabidopsis.
JOURNAL OF EXPERIMENTAL BOTANY.
2020.
Machover D., Rossi L., Hamelin J., Kopečný D.
Effects in cancer cells of the recombinant L-methionine gamma-lyase from Brevibacterium aurantiacum. Encapsulation in human erythrocytes for sustained L-methionine elimination.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.
2019.
Končitíková R., Vigouroux A., Kopečná M., Šebela M., Moréra S., Kopečný D.
Kinetic and structural analysis of human ALDH9A1.
BIOSCIENCE REPORTS.
2019.
Jaworek P., Kopečný D., Zalabák D., Šebela M., Kouřil Š., Hluska T., Končitíková R., Podlešáková K., Tarkowski P.
Occurrence and biosynthesis of cytokinins in poplar.
PLANTA.
2019.
Frömmel J., Končitíková R., Kopečný D., Soural M., Šebela M.
Oxidation of imidazole- and pyrazole-derived aldehydes by plant aldehyde dehydrogenases from the family 2 and 10.
CHEMICO-BIOLOGICAL INTERACTIONS.
2019.
Korasick DA., Končitíková R., Kopečná M., Hájková E., Šebela M., Kopečný D.
Structural and biochemical characterization of aldehyde dehydrogenase 12, the last enzyme of proline catabolism in plants.
JOURNAL OF MOLECULAR BIOLOGY.
2019.
Tichá T., Činčalová L., Kopečný D., Sedlářová M., Kopečná M., Luhová L., Petřivalský M.
Characterization of S-nitrosoglutathione reductase from Brassica and Lactuca spp. and its modulation during plant development.
Nitric Oxide - Biology and Chemistry.
2017.
Kopečná M., Vigouroux A., Vilím J., Končitíková R., Briozzo P., Hájková E., Jašková L., von Schwartzenberg K., Šebela M., Moréra S., Kopečný D.
The ALDH21 gene found in lower plants and some vascular plants codes for a NADP+-dependent succinic semialdehyde dehydrogenase.
In Kopečný D. (Eds.)
Plant Journal.
2017.
Hluska T., Dobrev PI., Tarkowská D., Frébortová J., Zalabák D., Kopečný D., Plíhal O., Kokáš F., Briozzo P., Zatloukal M., Motyka V., Galuszka P.
Cytokinin metabolism in maize: Novel evidence of cytokinin abundance, interconversions and formation of a new trans-zeatin metabolic product with a weak anticytokinin activity.
Plant Science.
2016.
Kopečný D., Končitíková R., Popelka H., Briozzo P., Vigouroux A., Kopečná M., Zalabák D., Šebela M., Skopalová J., Frébort I., Moréra S.
Kinetic and structural investigation of the cytokinin oxidase/dehydrogenase active site.
F E B S Journal.
2016.
Nisler J., Kopečný D., Končitíková R., Zatloukal M., Bazgier V., Berka K., Zalabák D., Briozzo P., Strnad M., Spíchal L.
Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase.
Plant Molecular Biology.
2016.
Groeme R., Airouche S., Kopečný D., Jaekel J., Savko M., Berjont N., Bussieres L., Le Mignon M., Jagic F., Zieglmayer P., Baron-Bodo V., Bordas-Le Floch V., Mascarell L., Briozzo P., Moingeon P.
Structural and functional characterization of the major allergen Amb a 11 from short ragweed pollen.
Journal of Biological Chemistry.
2016.
Frömmel J., Tarkowski P., Kopečný D., Šebela M.
The use of tomato aminoaldehyde dehydrogenase 1 for the detection of aldehydes in fruit distillates.
New Biotechnology.
2016.
Končitíková R., Vigouroux A., Kopečná M., Andree T., Bartoš J., Šebela M., Moréra S., Kopečný D.
Role and structural characterization of plant aldehyde dehydrogenases from family 2 and family 7.
Biochemical Journal.
2015.
Brocker C., Vasiliou M., Carpenter S., Carpenter C., Zhang Y., Wang X., Kotchoni SO., Wood AJ., Kirch H., Kopečný D., Nebert DW., Vasiliou V.
Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics.
Planta.
2013.
Kopečný D., Končitíková R., Tylichová M., Vigouroux A., Moskalíková H., Soural M., Šebela M., Moréra S.
Plant ALDH10 family: identifying critical residues for substrate specificity and trapping a thiohemiacetal intermediate.
Journal of Biological Chemistry.
2013.
Raus M., Kopečný D., Šebela M.
Programová aplikace pro předpověď výsledků štěpení proteinů.
Chemické listy.
2013.
Kubienová L., Kopečný D., Tylichová M., Briozzo P., Skopalová J., Šebela M., Navrátil M., Tache R., Luhová L., Barroso JB., Petřivalský M.
Structural and functional characterization of a plant S-nitrosoglutathione reductase from Solanum lycopersicum.
Biochimie.
2013.
Kopečná M., Blaschke H., Kopečný D., Vigouroux A., Končitíková R., Novák O., Kotland O., Strnad M., Moréra S., von Schwartzenberg K.
Structure and function of nucleoside hydrolases from Physcomitrella patens and maize catalyzing the hydrolysis of purine, pyrimidine, and cytokinin ribosides.
Plant Physiology.
2013.
Franc V., Šebela M., Řehulka P., Končitíková R., Lenobel R., Madzak C., Kopečný D.
Analysis of N-glycosylation in maize cytokinin oxidase/dehydrogenase 1 using a manual microgradient chromatographic separation coupled offline to MALDI-TOF/TOF mass spectrometry.
Journal of Proteomics.
2012.
Frömmel J., Soural M., Tylichová M., Kopečný D., Demo G., Wimmerová M., Šebela M.
Plant aminoaldehyde dehydrogenases oxidize a wide range of nitrogenous heterocyclic aldehydes.
Amino Acids.
2012.
KOPEČNÝ D., TYLICHOVÁ M., Snégaroff J., Popelková H., ŠEBELA M.
Carboxylate and aromatic active-site residues are determinants of high-affinity binding of omega-aminoaldehydes to plant aminoaldehyde dehydrogenases.
F E B S Journal.
2011.
STRÁNSKÁ J., Tylichová M., Kopečný D., Snégaroff J., Šebela M.
Biochemical characterization of pea ornithine-delta-aminotransferase: substrate specificity and inhibition by di- and polyamines.
Biochimie.
2010.
Kopečný D., Briozzo P., Popelková H., Šebela M., Končitíková R., Spíchal L., Nisler J., Madzak C., Frébort I., Laloue M., Houba-Hérin N.
Phenyl- and benzylurea cytokinins as competitive inhibitors of cytokinin oxidase/dehydrogenase: a structural study.
Biochimie.
2010.
Tylichová M., Kopečný D., Moréra S., Briozzo P., Lenobel R., Snégaroff J., Šebela M.
Structural and functional characterization of plant aminoaldehyde dehydrogenase from Pisum sativum with a broad specificity for natural and synthetic aminoaldehydes.
Journal of Molecular Biology.
2010.
Kopečný D., Šebela M., Briozzo P., Spíchal L., Houba-Hérin N., Mašek V., Joly N., Madzak C., Anzenbacher P., Laloue M.
Mechanism-based inhibitors of cytokinin oxidase/dehydrogenase attack FAD cofactor.
Journal of Molecular Biology.
2008.
Kopečný D., Šebela M., Briozzo P., Spichal L., Houba-Hérin N., Mašek V., Joly N., Madzak C., Anzenbacher P., Laloue M.
Mechanism-based inhibitors of cytokinin oxidase/dehydrogenase attack FAD cofactor.
Journal of Molecular Biology.
2008.
Stránská J., Kopečný D., Tylichová M., Snégaroff J., Šebela M.
Ornithine delta-aminotransferase: an enzyme implicated in salt tolerance in higher plants.
Plant Signaling & Behavior (print).
2008.
Tylichová M., Briozzo P., Kopečný D., Ferrero J., Moréra S., Joly N., Snégaroff J., Šebela M.
Purification, crystallization and preliminary crystallographic study of a recombinant plant aminoaldehyde dehydrogenase from Pisum sativum.
Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online.
2008.
Kopečný D., Tarkowski P., Majira A., Bouchez-Mahiout I., Nogué F., Lauriére M., Sandberg G., Laloue M., Houba-Hérin N.
Probing cytokinin homeostasis in Arabidopsis thaliana by constitutively overexpressing two forms of the maize cytokinin oxidase/dehydrogenase 1 gene.
Plant Science.
2006.
Massoneau A., Houba-Hérin N., Pethe C., Madzak C., Falque M., Mercy M., Kopečný D., Majira A., Rogowsky P., Laloue M.
Maize cytokinin oxidase genes: differential expression and cloning of two new cDNAs.
Journal of Experimental Botany.
2004.
Kopečný D., Briozzo P., Joly N., Houba-Hérin N., Madzak C., Pethe C., Laloue M.
Purification, crystallization and preliminary X-ray diffraction study of a recombinant cytokinin oxidase from Zea mays.
Acta Crystallographica Section D - Biological Crystalography.
2004.
DISERTAČNÍ PRÁCE
Kopečný D.
Structure and Function of Cytokinin Oxidase/Dehydrogenase. Modification of Enzymes.
Structure and Function of Cytokinin Oxidase/Dehydrogenase. Modification of Enzymes.
2006.
KAPITOLA V KNIZE
Kopečný D., Kaczorová D., Tarkowski P.
Occurrence, Interconversion, and Perception of Topolins in Poplar.
Meta-topolin: A Growth Regulator for Plant Biotechnology and Agriculture.
2021.
Galuszka P., Spíchal L., Kopečný D., Tarkowski P., Frébortová J., Šebela M., Frébort I.
Metabolism of plant hormones cytokinins and their function in signaling, cell differentiation and plant development.
Studies in Natural Products Chemistry.
2008.
ABSTRAKT
KOPEČNÝ D., TYLICHOVÁ M., ANDREE T., KONČITÍKOVÁ R., ŠEBELA M.
Biochemical characterization of a recombinant plant aldehyde dehydrogenase 7 from Pisum sativum and Zea mays.
F E B S Journal.
2011.
KOPEČNÝ D., TYLICHOVÁ M., ANDREE T., FRÖMMEL J., ŠEBELA M.
Biochemical characterization of a recombinant plant aldehyde dehydrogenase 7 from Pisum sativum (PsALDH7).
Bulletin of the Czech and Slovak Crystallographic Association.
2011.
ŠEBELA M., KONČITÍKOVÁ R., LENOBEL R., FRANC V., ŘEHULKA P., TYLICHOVÁ M., KOPEČNÝ D.
Structural and functional study on the glycosylation in maize cytokinin oxidase/dehydrogenase 1.
F E B S Journal.
2011.
ŠEBELA M., KONČITÍKOVÁ R., LENOBEL R., FRANC V., ŘEHULKA P., TYLICHOVÁ M., KOPEČNÝ D.
Structural and functional study on the glycosylation in maize cytokinin oxidase/dehydrogenase 1.
Bulletin of the Czech and Slovak Crystallographic Association.
2011.
Frömmel J., Moskalíková H., Soural M., Tylichová M., Kopečný D., Šebela M.
Exploring the active sites of plant aminoaldehyde dehydrogenases using natural and synthetic substrates.
Sborník příspěvků (Book of Abstracts).
2010.
Frömmel J., Moskalíková H., Soural M., Tylichová M., Kopečný D., Šebela M.
Exploring the active sites of plant aminoaldehyde dehydrogenases using natural and synthetic substrates.
Materials Structure in Chemistry, Biology, Physics and Technology.
2010.
Kopečný D., Popelková H., Briozzo P., Madzak C., Frébort I., Majira A., Laloue M., Houba-Hérin N., Šebela M.
Structural analysis of active site of cytokinin.
F E B S Journal.
2010.
Tylichová M., Kopečný D., Briozzo P., Moréra S., Snégaroff J., Šebela M.
Structural analysis of plant aminoaldehyde dehydrogenases.
F E B S Journal.
2010.
Tylichová M., Kopečný D., Briozzo P., Moréra S., Snégaroff J., Šebela M.
Structural analysis of plant aminoaldehyde dehydrogenases.
Materials Structure in Chemistry, Biology, Physics and Technology.
2010.
Tylichová M., Kopečný D., Briozzo P., Moréra S., Snégaroff J., Šebela M.
Characterization of aminoaldehyde dehydrogenases from pea and tomato.
Plant Abiotic Stress - from signaling to development; 2nd meeting of the INPAS, May 14-17, 2009, Tartu, Estonia; Book of Abstracts.
2009.
Tylichová M., Kopečný D., Briozzo P., Moréra S., Snégaroff J., Šebela M.
Characterization of aminoaldehyde dehydrogenases from pea and tomato.
Amino Acids.
2009.
Tylichová M., Kopečný D., Briozzo P., Moréra S., Snégaroff J., Šebela M.
Characterization of aminoaldehyde dehydrogenases from pea and tomato.
XIIIth Workshop of Biochemists and Molecular Biologists (XIII. Setkání biochemiků a molekulárních biologů), April 14-15, 2009, Masaryk University, Brno, Czech Republic; Sborník příspěvků (Book of Abstracts),.
2009.
Stránská J., Snégaroff J., Tylichová M., Kopečný D., Šebela M.
Cloning and expression of plant ornithine delta-aminotransferase.
XIIth Workshop of Biochemists and Molecular Biologists (XII. Setkání biochemiků a molekulárních biologů), Book of Abstracts.
2008.
Stránská J., Snégaroff J., Tylichová M., Kopečný D., Šebela M.
Cloning and expression of plant ornithine delta-aminotransferase.
F E B S Journal.
2008.
Stránská J., Snégaroff J., Tylichová M., Kopečný D., Šebela M.
Cloning and expression of plant ornithine delta-aminotransferase.
21st Joint Congress of the Czech and Slovak Societies for Biochemistry and Molecular Biology (21. biochemický sjezd), Sborník přednášek a posterů.
2008.
Tylichová M., Briozzo P., Kopečný D., Joly N., Snégaroff J., Šebela M.
Purification and crystallization of recombinant plant aminoaldehyde dehydrogenase from Pisum sativum.
XIIth Workshop of Biochemists and Molecular Biologists (XII. Setkání biochemiků a molekulárních biologů), Book of Abstracts.
2008.
Tylichová M., Briozzo P., Kopečný D., Snégaroff J., Šebela M.
Purification, characterization and crystallization of a recombinant plant aminoaldehyde dehydrogenase.
Biogenic Amines: Biochemical, Physiological and Clinical Aspects (International Congress), Book of Abstracts.
2008.
Kopečný D., Popelková H., Madzak C., Briozzo P., Šebela M., Laloue M., Houba-Hérin N.
Site-directed mutagenesis of maize cytokinin oxidase/dehydrogenase.
Physiologia Plantarum.
2008.
Kopečný D., Popelková H., Madzak C., Briozzo P., Šebela M., Laloue M., Houba-Hérin N.
Site-directed mutagenesis of maize cytokinin oxidase/dehydrogenase.
XIIth Workshop of Biochemists and Molecular Biologists (XII. Setkání biochemiků a molekulárních biologů), Book of Abstracts.
2008.
Tylichová M., Briozzo P., Kopečný D., Snégaroff J., Šebela M.
Structure and function of pea seedling aminoaldehyde dehydrogenase.
Physiologia Plantarum.
2008.
Tylichová M., Briozzo P., Kopečný D., Joly N., Snégaroff J., Šebela M.
Structure and function of pea seedling aminoaldehyde dehydrogenase.
21st Joint Congress of the Czech and Slovak Societies for Biochemistry and Molecular Biology (21. biochemický sjezd), Book of Abstracts.
2008.
Tylichová M., Snégaroff J., Kopečný D., Šebela M.
Cloning and expression of plant aminoaldehyde dehydrogenase.
XIth Workshop of XIth Workshop of Biochemists and Molecular Biologists (XI. Setkání biochemiků a molekulárních biologů), Book of Abstracts (Sborník příspěvků).
2007.
Tylichová M., Snégaroff J., Kopečný D., Šebela M.
Preparation of recombinant pea aminoaldehyde dehydrogenase.
Bulletin České společnosti experimentální biologie rostlin.
2007.
Mašek V., Anzenbacher P., Kopečný D., Šebeta M.
RAMAN SPEKTROSCOPIC STUDY OF BINDING OF SELECTIVE INHIBITORS HA-1 AND HA-8 TO ZEA MAYS CYTOKININ OXIDASE/DEHYDROGENASE.
Seminář k vědeckovýzkumnému záměru MŠM 6198959216, Karlov p. Pradědem, 10. - 12. květen 2007.
2007.
Kopečný D., Šebela M., Briozzo P., Spíchal L., Houba-Hérin N., Mašek V., Lenobel R., Joly N., Madzak C., Laloue M.
Reaction of cytokinin oxidase/dehydrogenase with unsaturated substrate analogs and urea derivatives.
XIth Workshop of Biochemists and Molecular Biologists (XI. Pracovní setkání biochemiků a molekulárních biologů), Book of Abstracts (Sborník příspěvků).
2007.
Kopečný D., Šebela M., Briozzo P., Houba-Hérin N., Popelková H., Madzak C., Laloue M.
Structure and function of cytokinin oxidase/dehydrogenase.
Bulletin České společnosti experimentální biologie rostlin.
2007.
PŘEDNÁŠKA NEBO POSTER
Kubienová L., Kopečný D., Tylichová M., Jahnová J., Piterková J., Sedlářová M., Briozzo P., Skopalová J., Šebela M., Navrátil M., Tache R., Luhová L., Barroso J., Petřivalský M.
S-nitrosoglutathione reductase from Solanum spp. – crystal structure, biochemical characterization and role in plant development and stress responses.
2012.
Jahnová J., Kubienová L., Piterková J., Tichá T., Kopečný D., Tylichová M., Luhová L., Petřivalský M.
S-nitrosoglutathionreduktasa – klíčový enzym regulace S-nitrosylace v odpovědi rostlin na stresové podmínky.
2012.
Mašek V., Anzenbacher P., Kopečný D., Šebela M.
RAMAN SPECTROSCOPIC STUDY OF BINDING OF SELECTIVE INHIBITORS HA-1 AND HA-8 TO ZEA MAYS CYTOKININ OXIDASE/DEHYDROGENASE.
12-th ECSBM, Paris, 1-6 september 2007.
2007.
Mašek V., Anzenbacher P., Kopečný D., Šebeta M.
RAMAN SPEKTROSCOPIC STUDY OF BINDING OF SELECTIVE INHIBITORS HA-1 AND HA-8 TO ZEA MAYS CYTOKININ OXIDASE/DEHYDROGENASE.
Seminář k vědeckovýzkumnému záměru MSM6198959216.
2007.
Uživatel nepovolil zobrazení dat v Portále UP.