Prof. RNDr. Jana KAŠPÁRKOVÁ, Ph.D.

Zástupný obrázek
Kontaktní údaje

585634154, 728217620

jana.kasparkova@upol.cz

jana@ibp.cz

Katedra biofyziky

Přírodovědecká fakulta

Šlechtitelů 27 - objekt 49 (C)

1.13A

profesor

molekulární biofyzika a farmakologie, struktura a interakce nukleových kyselin, vztah mezi strukturou a farmakologickou aktivitou protinádorově účinných látek

ČLÁNEK
Prachařová J., Cyříková T., Berecka M., Biersack B., Kašpárková J., Brabec V. Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran. CHEMICO-BIOLOGICAL INTERACTIONS. 2024.
Marková L., Maji M., Kostrhunová H., Novohradský V., Kašpárková J., Gibson D., Brabec V. Multi-action Pt(IV) prodrugs releasing cisplatin and dasatinib are potent anticancer and anti-invasive agents displaying synergism between the two drugs. JOURNAL OF MEDICINAL CHEMISTRY. 2024.
Cervinka J., Hernández-García A., Bautista D., Markova L., Kostrhunova H., Malina J., Kašpárková J., Santana D., Brabec V., Ruiz J. New cyclometalated Ru(II) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes. Inorganic Chemistry Frontiers. 2024.
Kašpárková J., Novohradský V., Ruiz J., Brabec V. Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. CHEMICO-BIOLOGICAL INTERACTIONS. 2024.
Sarkar A., Novohradský V., Maji M., Babu T., Marková L., Kostrhunová H., Kašpárková J., Gandin V., Brabec V., Gibson D. Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023.
Schleser SW., Krytovych O., Ziegelmeier T., Gross E., Kašpárková J., Brabec V., Weber T., Schobert R., Mueller T. Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells. MOLECULES. 2023.
Kostrhunová H., McGhie BS., Marková L., Nováková O., Kašpárková J., Aldrich-Wright JR., Brabec V. Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY. 2023.
Novohradský V., Marková L., Kostrhunová H., Kašpárková J. Pt(II) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism. Inorganic Chemistry Frontiers. 2022.
Červinka J., Gobbo A., Biancalana L., Kašpárková J. Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. JOURNAL OF MEDICINAL CHEMISTRY. 2022.
Masaryk L., Nemec I., Kašpárková J., Brabec V., Štarha P. Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes. Dalton Transactions. 2021.
Nunhart P., Konkolova E., Janovec L., Kašpárková J., Malina J., Brabec V. Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines. CHEMICAL PAPERS. 2020.
Crlíková H., Malina J., Novohradsky V., Kostrhunová H., Vasdev R., Crowley J., Kašpárková J., Brabec V. Antiproliferative Activity and Associated DNA Interactions of [Co2L3](6 ) Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole Ligands. ORGANOMETALLICS. 2020.
Crlíková H., Kostrhunová H., Prachařová J., Kozsup M., Nagy S., Buglyó P., Brabec V., Kašpárková J. Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2020.
Litecká M., Hreusová M., Kašpárková J. Low-dimensional compounds containing bioactive ligands. Part XIV: High selective antiproliferative activity of tris(5-chloro-8-quinolinolato)gallium (III) complex against human cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2020.
Litecká M., Prachařová J., Kašpárková J., Brabec V. Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells. POLYHEDRON. 2020.
Nagy I., Farkas ER., Kašpárková J., Kostrhunová H., Brabec V., Buglyó P. Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate. JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2020.
Kostrhunová H., Petruzzella E., Gibson D., Kašpárková J., Brabec V. A new anticancer Pt(IV) prodrug that acts by mechanisms involving DNA damage and different epigenetic effects. CHEMISTRY-A EUROPEAN JOURNAL. 2019.
Gold M., Mujahid Y., Ahmed K., Kašpárková J. A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2019.
Janočková J., Korábečný J., Plšíková J., Kašpárková J., Brabec V. In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2019.
Kozsup M., Farkas E., Bényei AC., Kašpárková J., Crlíková H., Brabec V., Buglyó P. Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs. JOURNAL OF INORGANIC BIOCHEMISTRY. 2019.
Chen F., Soldevila-Barreda J., Romero-Canelón I., Coverdale J., Song J., Clarkson G., Kašpárková J., Habtemariam A., Brabec V., Wolny J., Schünemann V., Sadler P. Effect of sulfonamidoethylenediamine substituents in Ru-II arene anticancer catalysts on transfer hydrogenation of coenzyme NAD( ) by formate. DALTON TRANSACTIONS. 2018.
Lemmerhirt H., Behnisch S., Bodtke A., Lillig CH., Kašpárková J., Brabec V., Bednarski PJ., Pazderová L. Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA. Journal of Inorganic Biochemistry. 2018.
Štarha P., Trávníček Z., Crlíková H., Vančo J., Kašpárková J., Dvořák Z. Half-Sandwich Ir(III) Complex of N1-Pyridyl-7-azaindole Exceeds Cytotoxicity of Cisplatin at Various Human Cancer Cells and 3D Multicellular Tumor Spheroids. ORGANOMETALLICS. 2018.
Parajdi-Losonczi P., Buglyo P., Crlíková H., Kašpárková J., Lihi N., Farkas E. Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding. NEW JOURNAL OF CHEMISTRY. 2018.
Schmitt F., Kašpárková J., Brabec V., Begemann G., Schobert R., Biersack B. New (arene)ruthenium(II) complexes of 4-aryl-4H-naphthopyrans with anticancer and anti-vascular activities. JOURNAL OF INORGANIC BIOCHEMISTRY. 2018.
Prachařová J., Intini F., Natile G., Kašpárková J., Brabec V. Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights. INORGANICA CHIMICA ACTA. 2018.
Novohradský V., Yellol J., Stuchlíková O., Santana DM., Kostrhunová H., Yellol G., Kašpárková J., Bautista D., Ruiz J., Brabec V. Organoruthenium Complexes with CN Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action. Chemistry: A European Journal. 2017.
Perfahl S., Bodtke A., Prachařová J., Kašpárková J., Brabec V., Cuadrado J., Sturup S., Schulzke C., Bednarski PJ. Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity. Inorganica Chimica Acta. 2017.
Hrabina O., Kašpárková J., Suchánková T., Novohradský V., Guo Z., Brabec V. Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex. Metallomics. 2017.
Bečka M., Vilková M., Salem OM., Kašpárková J., Brabec V., Kožurková M. 3-[(E)-(acridin-9 '-ylmethylidene)amino]-1-substituted thioureas and their biological activity. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2017.
Prachařová J., Radošová Muchová T., Dvořák Tomaštíková E., Intini F., Pacifico C., Natile G., Kašpárková J., Brabec V. Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage. Dalton Transactions (print). 2016.
Janočková J., Zilecká E., Kašpárková J., Brabec V., Soukup O., Kuča K., Kožurková M. Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity. Molecular BioSystems. 2016.
Brabec V., Vrána O., Nováková O., Kašpárková J. Comment on "Delivering a photosensitive transplatin prodrug to overcome cisplatin drug resistance'' by H. Song, W. Li, R. Qi, L. Yan, X. Jing, M. Zheng and H. Xiao, Chem. Commun., 2015, 51, 11493. Chemical Communications. 2016.
Schmitt F., Donnelly K., Muenzer J., Rehm T., Novohradský V., Brabec V., Kašpárková J., Albrecht M., Schobert R., Mueller T. Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold. Journal of Inorganic Biochemistry. 2016.
Parajdi-Losonczi PL., Bényei AC., Kováts É., Timári I., Radošová Muchová T., Novohradský V., Kašpárková J., Buglyó P. [(eta(6)-p-cymene)Ru(H2O)(3)](2) binding capability of aminohydroxamates - A solution and solid state study. Journal of Inorganic Biochemistry. 2016.
Brabec V., Kašpárková J., Kostrhunová H., Farrel N. Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes. Scientific Reports. 2016.
Vrána O., Novohradský V., Medříková Z., Burdíková J., Stuchlíková O., Kašpárková J., Brabec V. Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic. Chemistry: A European Journal. 2016.
Salem OM., Vilková M., Janočková J., Jendželovský R., Fedoročko P., Zilecká E., Kašpárková J., Brabec V., Imrich J., Kožurková M. New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds. International Journal of Biological Macromolecules. 2016.
Brabec V., Prachařová J., Štěpánková J., Sadler P., Kašpárková J. Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex. Journal of Inorganic Biochemistry. 2016.
Zajac J., Kostrhunová H., Novohradský V., Vrána O., Raveendran R., Gibson D., Kašpárková J., Brabec V. Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin. Journal of Inorganic Biochemistry. 2016.
Münzner JK., Rehm T., Biersack .., Casini A., de Graaf IAM., Worawutputtapong .., Noor .., Kempe R., Brabec V., Kašpárková J., Schobert R. Adjusting the DNA interaction and anticancer activity of Pt(II) N-heterocyclic carbene complexes by steric shielding of the trans leaving group. Journal of Medicinal Chemistry. 2015.
Patalenszki J., Biro L., Benyei .., Radošová Muchová T., Kašpárková J., Buglyo P. Half-sandwich complexes of ruthenium, osmium, rhodium and iridium with DL-methionine or S-methyl-L-cysteine: a solid state and solution equilibrium study. RSC Advances (online). 2015.
Janočková .., Plšíková J., Kašpárková J., Brabec V., Jendželovský R., Mikeš J., Koval J., Hamuľ áková S., Fedoročko P., Kuča K., Kožurková M. Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. European Journal of Pharmaceutical Sciences. 2015.
Novohradský V., Zerzanková L., Štěpánková .., Vrána O., Raveendran R., Gibson D., Kašpárková J., Brabec V. New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells. Biochemical Pharmacology. 2015.
Štarha P., Trávníček Z., Dvořák Z., Radošová Muchová T., Prachařová J., Vančo J., Kašpárková J. Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles. PLoS One. 2015.
Brabec V., Prachařová J., Nováková O., Gibson D., Kašpárková J. The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions. Dalton Transactions (print). 2015.
Novohradský V., Zerzánková L., Štěpánková J., Kisová A., Kostrhunová H., Zhe L., Sadler PJ., Kašpárková J., Brabec V. A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex. Metallomics. 2014.
Novohradský V., Zerzánková L., Štěpánková J., Vrána O., Raveendran R., Gibson D., Kašpárková J., Brabec V. Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands. Journal of Inorganic Biochemistry. 2014.
Frýbortová M., Nováková O., Štěpánková J., Novohradský V., Gibson D., Kašpárková J., Brabec V. Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand. Journal of Inorganic Biochemistry. 2013.
Zhao Y., Woods JA., Farrer NJ., Robinson KS., Prachařová J., Kašpárková J., Nováková O., Li H., Salassa L., Pizarro AM., Clarkson GJ., Song L., Brabec V., Sadler PJ. Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry: A European Journal. 2013.
Muchová T., Prachařová J., Štarha P., Olivová R., Vrána O., Benešová B., Kašpárková J., Trávníček Z., Brabec V. Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells. Journal of Biological Inorganic Chemistry. 2013.
Prachařová J., Nováková O., Kašpárková J., Gibson D., Brabec V. Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers. Pure and Applied Chemistry. 2013.
Muchová T., Quintal SM., Farrell N., Brabec V., Kašpárková J. Antitumor bifunctional dinuclear Pt-II complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions. Journal of Biological Inorganic Chemistry. 2012.
Mlčoušková J., Malina J., Novohradský V., Kašpárková J., Komeda S., Brabec V. Energetics, conformation, and recognition of DNA duplexes containing a major adduct of antitumor azolato-bridged dinuclear Pt II complex. Biochimica et Biophysica Acta - General Subjects. 2012.
Olivová R., Štěpánková J., Muchová T., Novohradský V., Nováková O., Vrána O., Kašpárková J., Brabec V. Mechanistic insights into toxic effects of a benzotriazolate-bridged dinuclear platinum(II) compound in tumor cells. Inorganica Chimica Acta. 2012.
Suchánková T., Kubíček K., Kašpárková J., Brabec V., Kozelka J. Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix. Journal of Inorganic Biochemistry. 2012.
Stěpánková J., Studenovský M., Malina J., KAŠPÁRKOVÁ J., Lišková B., Nováková O., Ulbrich K., Brabec V. DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analog of doxorubicin. Biochemical Pharmacology. 2011.
Malina J., KAŠPÁRKOVÁ J., Farrell NP., Brabec V. Walking of antitumor bifunctional trinuclear Pt II complex on double-helical DNA. Nucleic Acids Research. 2011.
Zerzánková L., Suchánková T., Vrána O., Farrell N., Brabec V., Kašpárková J. Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles. Biochemical Pharmacology. 2010.
Suchánková T., Vojtíšková M., Reedijk J., Brabec V., Kašpárková J. DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]. Relations to their different antitumor effects. Journal of Biological Inorganic Chemistry. 2009.
Nováková O., Malina J., Kašpárková J., Halámiková A., Bernard V., Intini F., Natile G., Brabec V. Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+. Chem Eur J, 15, 6211-6221. Chemistry: A European Journal. 2009.
Ruhayel R.A.., Moniodis J.J.., Yang X., Kašpárková J., Brabec V., Bernes-Price S., Farrell N. Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with the 5'-5' directional isomer. Chemistry: A European Journal. 2009.
Castellano-Castillo M., Kostrhunová H., Marini V., Kašpárková J., Sadler P., Malinge J., Brabec V. Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry. 2008.
Kašpárková J., Marini V., Bursová V., Brabec V. Biophysical Studies on the stability of DNA intrastrand cross-links of transplatin. Biophysical Journal. 2008.
Bugarcic T., Nováková O., Halámiková A., Zerzánková L., Vrána O., Kašpárková J., Habtemariam A., Pardone S., Sadler P., Brabec V. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry. 2008.
Bugarcic T., Habtemariam A., Štěpánková J., Heringová P., Kašpárková J., Deeth J.R.., Johnstone R.D.L., Prescimone A.., Parsons S.., Parkin A.., Brabec V., Sadler P. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry. 2008.
KAPITOLA V KNIZE
Brabec V., Kašpárková J. Role of DNA repair in antitumor effects of platinum drugs. Metal Complex - DNA Interactions. 2009.
ABSTRAKT
Štarha P., Trávníček Z., Dvořák Z., Kašpárková J. Anticancer platinum(II) complexes involving 7-azaindole derivatives. Book of Abstracts. 2014.
Brabec V., Prachařová J., Kašpárková J., Sadler PJ. Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells. Journal of Biological Inorganic Chemistry. 2014.
Kašpárková J., Mlčoušková J., Brabec V. Light-potentiated Cytotoxicity of Carboplatin in Tumor Cells: Enhanced DNA Binding. Journal of Biological Inorganic Chemistry. 2014.

Uživatel nepovolil zobrazení dat v Portále UP.

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